Neonatal Necrotizing Enterocolitis – Inflammation and Intestinal Immaturity

Neonatal intestinal dysbiosis in necrotizing enterocolitis

Necrotizing Enterocolitis (NEC) is one of the most devastating gastrointestinal diseases in neonates, particularly among preterm infants in whom surgical NEC is the leading cause of morbidity. NEC pathophysiology occurs in the hyper-reactive milieu of the premature gut after bacterial colonization. The resultant activation of the TLR4 pathway appears to be a strongly contributing factor. Advanc...

Ischaemic enterocolitis Infarction of the intestinal tract Intestinal gangrene Haemorrhagic enterocolitis Neonatal necrotizing enterocolitis Uraemic enterocolitis

A supply of oxygenated blood appropriate to the tissue needs of the gut is essential to the maintenance of its vital functions. The splanchnic vascular system serves this purpose and much of our knowledge of ischaemic bowel disease has developed from studies of radiological and pathological abnormalities of this system. The purpose of this paper is to summarize current information concerning th...

Neonatal Necrotizing Enterocolitis

Neonatal Necrotizing Enterocolitis

Necrotizing enterocolitis (NEC) is a gastrointestinal disease that mostly affects premature infants. It involves infection and inflammation that causes destruction of the bowel. Although it affects only 1 in 2,000 to 4,000 births, or between 1 and 5% of neonatal intensive care unit admissions, NEC is the most common and serious gastrointestinal disorder among hospitalized preterm infants. We pr...

Neonatal Necrotizing Enterocolitis: Radiological Manifistations

Objective: The aim of this study is to determine the characteristics radiological manifestations and risk factors in neonates with necrotizing enterocolitis (NEC). Methods: A prospective study over on year starting from January 2008, conducted on 55 neonates with suspected NEC admitted at Children Hospital, Cairo University. Serial X-ray for all neonates were done and assessed Results: 31 (56.4...